Abstract
Introduction: Infective endocarditis (IE) is an endothelial damage of the endocardium caused by infection. The highest mortality and morbidity rates of etiologic agents are associated with Staphylococcus aureus. Accordingly, the knowledge of different risk factors for IE caused by S. aureus is necessary.
Methods: This analytical cross-sectional study included 200 patients referred to the Shahid Rajaee Cardiovascular, Medical, and Research Center from 25 November 2011 to 12 December 2019. A total of 139 patients with S. aureus bacteremia (SAB) were analyzed, with 48 diagnosed with endocarditis. Data were evaluated using SPSS software, employing descriptive and inferential statistics, including logistic regression, with a significance level set at P<0.05.
Findings: The mean age of the patients is (56.61±16.58), and 85 (61.2%) persons are male. Forty-eight patients (34.5%) are diagnosed with S. aureus endocarditis according to Duke criteria. In this study, the following risk factors were significantly associated with S. aureus endocarditis: age (P=0.003), long-term bacteremia (P=0.041), prosthetic heart valve (P=0.016), pre-existing IE (P=0.048), and embolic events (P=0.039).
Conclusion: According to the findings, a significant number of patients with SAB have IE with different risk factors. Future studies with a larger sample size are recommended to detect IE risk factors.