Maad Rayan Publishing Company Biomedicine Advances 3080-0382 2 3 2025 07 01 The significance of family history in premature coronary artery disease: A call for early intervention 102 103 10.34172/bma.15 EN Neda Roshanravan https://orcid.org/0000-0002-8173-6532 Samad Ghaffari https://orcid.org/0000-0001-6806-9387 Journal Article 10.34172/bma.15 2025 03 19 2025 06 15 Despite remarkable progress in the prevention and treatment of coronary artery disease (CAD), it remains the leading cause of death worldwide. The strong association between family history and premature CAD requires more attention. This association appears to be an avenue towards improved risk prediction and the creation of innovative treatments.